BioArchive® System


 
  • Specifically designed for stem cells storage
  • Cleared by U.S. Food and Drug Administration (FDA)
  • Adopted by 129 cord blood banks in 37 countries
  • Adopted by worldwide large blood banks and 90% cord blood banks in Europe, as well as New York Blood Centre which performed most transplants worldwide
  • Provided over 75% stem cell samples of global cord blood transplants17
  • Survival rate is 10% higher than traditional tanks after transplant15
  • Robotic storage and retrieval system
  • Closed system handling, eliminating the TWEs occurred in traditional tanks, which affect stem cells viability for future transplant18
  • Use of liquid nitrogen (stable temperature at -196˚C) as storage media, which is recommended by reports for long-term stem cells storage19
  • Built-in computerized monitoring system with precise storage record. No external equipments needed
  • Liquid nitrogen reservoir can maintain stable temperature for more than 50 days without electricity supply

Adopted by Worldwide Large Blood Banks and HealthBaby

FDA Cleared, never been compulsory recalled 20,21. Worldwide large blood banks implemented the BioArchive system to enhance the efficiency and quality of cord blood storage. In addition, 90% of the cord blood bank in Europe adopted BioArchive® system. It proves that this system is globally well recognized.

HealthBaby Consultant
 

Cell Viability is the Key of Successful Rate of Transplants

Storing cord blood and umbilical cord is a lifetime safeguard for your children and families. No one wants to have chances to use one day, but if it really happens, have you ever thought of low viability of stem cells will let cord blood and umbilical cord lose its functions? HealthBaby introduced BioArchive® liquid nitrogen storage system which is adopted by most of public cord blood bank in globe (including New York Cord Blood Center, Tokyo Cord Blood Bank and worldwide large blood banks), the purpose is to give the best safeguard for parents.

Use of liquid nitrogen (stable temperature at -196°C) as storage media is recommended by reports for long-term stem cells storage19. Only liquid nitrogen can keep stable -196°C amd cord blood stem cells will suspend all physiological activities and remain dormant. On the contrary, other cord blood banks claimed that stem cells can be stored at 135 ℃ for permanent storage while there is no scientific evidence to prove so. And using traditional vapor nitrogen tank will lead to temperature fuctuation resulting from transient exposure to surrounding air while the stem cells are being cryopreserved, taken out, transported and transferred to vapor nitrogen tanks for storage. Vapor Nitrogen combined with TWEs will lead to loss of viability.

HealthBaby Consultant

 

BioArchive® - The Best Stem Cells Storage Quality


 

BioArchive® System

Traditional Tanks

Specificity
  • FDA cleared, specifically designed for stem cells storage
  • No compulsory recall by FDA due to stem cells quality20,21
  • For general biological samples storage
  Reassurance to you Exclusive advanced technology to preserve baby's precious cord blood and cord stem cells sample.
Storage Media
  • Liquid nitrogen(-196˚C)
  • Stable temperature to maintain optimum stem cells viability22,23
  • Constant temperature, permanent storage for over 1000 years19
  • Liquid nitrogen reservoir can maintain stable temperature for more than 50 days without electricity supply
  • Vapor nitrogen(-130˚C ~ -190˚C)
  • Fluctuated temperature with continuous TWEs and low stem cells viability^
  • No scientific evidence that vapor nitrogen can be used for long-term storage
  • Samples in vapor nitrogen can only be kept ~20 days
Reassurance to you To guarantee stem cells viability, only HealthBaby adopts the costlier liquid nitrogen for stem cells storage, to ensure all stem cells are kept at stable -196℃ among all private cord blood banks in Hong Kong.19
Design and Operation
  • Closed design with stable storage temperature
  • Independent access of samples by periscope without affecting others
  • Eradicated TWEs, high stem cells viability guaranteed
  • Built-in 24-hour surveillance system for instant alarm
  • Manual mode to access samples for contingency
  • Contains sample records only, no risk of hacking attacks to client information
  • Open system causing inconsistent temperature inside the tank25, and increasing the risk of bacterial contamination upon samples storage and retrieval
  • Shared compartment, accessing of one sample will also affect all other samples' stem cells viability18
  • ~200º C temperature difference (From -190˚C vapor phase to 20˚C room temperature) when being accessed. Frequent TWEs will cause stem cells damage (~2-4% loss)clarify
  • Relyed on external surveillance system which is outdated and not all-rounded
  • Manual operation with high risk of human errors
Reassurance to you Automated closed system can avoid manual mistakes and TWEs which would affect the quality of cord blood and cord stem cells.
Controlled Rate Freezing
  • Built-in controlled rate freezer and eradicates TWEs
  • Steady freezing rate at 2.8℃/min for optimal stem cells condition
  • External freezing procedure causing samples to get exposed to room temperature from -190℃ before storage. Extreme temperaure difference causes stem cells serious damage.(2-4% loss)
  • Prolonged freezing time(~120 min) causes storage delay
Reassurance to you Exclusive built-in controlled rate freezer allows the processing to be completed within a short period of time.
Stem Cells Quality
  • Over 97% viable CD34+ cellsclarify, unsurpassed among other cryopreservation systems
  • Delivered up to 94% post-thaw cell viability13
  • Vapor Nitrogen combined with TWEs lead to 20% loss of viability26
Reassurance to you Using closed system and liquid nitrogen as storage media can maintain stem cells to their highest viability for future use.
Successful Transplants
  • Survival rate is 10% higher than traditional tanks after transplant14
  • Provided over 75% samples of successful transplants worldwide
  • Very few cases
Reassurance to you Survival rate of patient who received stem cells for transplant from BioArchive® System was 10% higher than those from using traditional vapor nitrogen storage system, providing trusted health protection to every expectant parent.
Global Usage
  • Adopted by over 80% Netcord’s cord blood banks
  • Adopted by most public cord blood banks worldwide(including New York Cord Blood Center, Tokyo Cord Blood Bank and worldwide large blood banks). Since the cord blood samples are for local public use, the quality requirement is much higher than that of private blood bank, to ensure all samples reaching transplant standard
  • Adopted by 60% cord blood banks in developed countries
  • Adopted by some private cord blood banks for cost saving concern
Reassurance to you The only storage system in Hong Kong with the highest global quality recognition, incomparable by other private cord blood banks.
Cross Contamination
  • No cross contamination record
  • No matter the cord blood stores in liquid nitrogen or vapor nitrogen, a cross-contamination might happen if containers are not airtight. Only sealed containers can eliminate eventual cross contaminations24,25
  • Rumors in market that liquid nitrogen caused cross-contamination is false
  • Reports showed sealed TG compartment molded freezing bags with liquid nitrogen storage can eradicate cross contaminationclarify
  • Traditional tanks have no "Anti-Contamination" function and beware of this misleading term used by other cord blood banks
  • Cross contamination cases happpened25,clarify

 

Transient Warming Events(TWEs) - Reduce Stem Cells Viability and Affect Transplant Quality


TWEs refers to temperature fluctuation resulting from transient exposure to surrounding air while the stem cells are being cryopreserved, taken out, transported and transferred to vapor nitrogen tanks for storage since they must operate in coordination with an external and independent freezing device. Such kind of repetitive temperature fluctuation will finally cause stem cells bursted and even died. Research report states that TWEs will reduce the number of stem cells even though it does not reach the significant level (>5%) in statistics. The fact is that millions of stem cells are lost due to TWEs18. Another report shows that Vapor Nitrogen combined with TWEs can lead to 20% loss of viability26.

 

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