BioArchive^® System

Specifically designed for stem cells storage
Cleared by U.S. Food and Drug Administration (FDA)
Adopted by 129 cord blood banks in 37 countries
Adopted by worldwide large blood banks and 90% cord blood banks in Europe, as well as New York Blood Centre which performed most transplants worldwide
Provided over 75% stem cell samples of global cord blood transplants¹⁷
Survival rate is 10% higher than traditional tanks after transplant¹⁵
Robotic storage and retrieval system
Closed system handling, eliminating the TWEs occurred in traditional tanks, which affect stem cells viability for future transplant¹⁸
Use of liquid nitrogen (stable temperature at -196˚C) as storage media, which is recommended by reports for long-term stem cells storage¹⁹
Built-in computerized monitoring system with precise storage record. No external equipments needed
Liquid nitrogen reservoir can maintain stable temperature for more than 50 days without electricity supply

Adopted by Worldwide Large Blood Banks and HealthBaby

FDA Cleared, never been compulsory recalled ^20,21. Worldwide large blood banks implemented the BioArchive system to enhance the efficiency and quality of cord blood storage. In addition, 90% of the cord blood bank in Europe adopted BioArchive^® system. It proves that this system is globally well recognized.

Cell Viability is the Key of Successful Rate of Transplants

Storing cord blood and umbilical cord is a lifetime safeguard for your children and families. No one wants to have chances to use one day, but if it really happens, have you ever thought of low viability of stem cells will let cord blood and umbilical cord lose its functions? HealthBaby introduced BioArchive^® liquid nitrogen storage system which is adopted by most of public cord blood bank in globe (including New York Cord Blood Center, Tokyo Cord Blood Bank and worldwide large blood banks), the purpose is to give the best safeguard for parents.

Use of liquid nitrogen (stable temperature at -196°C) as storage media is recommended by reports for long-term stem cells storage¹⁹. Only liquid nitrogen can keep stable -196°C amd cord blood stem cells will suspend all physiological activities and remain dormant. On the contrary, other cord blood banks claimed that stem cells can be stored at 135 ℃ for permanent storage while there is no scientific evidence to prove so. And using traditional vapor nitrogen tank will lead to temperature fuctuation resulting from transient exposure to surrounding air while the stem cells are being cryopreserved, taken out, transported and transferred to vapor nitrogen tanks for storage. Vapor Nitrogen combined with TWEs will lead to loss of viability.

HealthBaby Consultant

BioArchive^® - The Best Stem Cells Storage Quality

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	BioArchive^® System	Traditional Tanks
Specificity	FDA cleared, specifically designed for stem cells storage No compulsory recall by FDA due to stem cells quality^20,21	For general biological samples storage
	Reassurance to you Exclusive advanced technology to preserve baby's precious cord blood and cord stem cells sample.
Storage Media	Liquid nitrogen(-196˚C) Stable temperature to maintain optimum stem cells viability^22,23 Constant temperature, permanent storage for over 1000 years¹⁹ Liquid nitrogen reservoir can maintain stable temperature for more than 50 days without electricity supply	Vapor nitrogen(-130˚C ~ -190˚C) Fluctuated temperature with continuous TWEs and low stem cells viability^{^} No scientific evidence that vapor nitrogen can be used for long-term storage Samples in vapor nitrogen can only be kept ~20 days
Reassurance to you	To guarantee stem cells viability, only HealthBaby adopts the costlier liquid nitrogen for stem cells storage, to ensure all stem cells are kept at stable -196℃ among all private cord blood banks in Hong Kong.¹⁹。
Design and Operation	Closed design with stable storage temperature Independent access of samples by periscope without affecting others Eradicated TWEs, high stem cells viability guaranteed Built-in 24-hour surveillance system for instant alarm Manual mode to access samples for contingency Contains sample records only, no risk of hacking attacks to client information	Open system causing inconsistent temperature inside the tank²⁵, and increasing the risk of bacterial contamination upon samples storage and retrieval Shared compartment, accessing of one sample will also affect all other samples' stem cells viability¹⁸ ~200º C temperature difference (From -190˚C vapor phase to 20˚C room temperature) when being accessed. Frequent TWEs will cause stem cells damage (~2-4% loss)^clarify Relyed on external surveillance system which is outdated and not all-rounded Manual operation with high risk of human errors
Reassurance to you	Automated closed system can avoid manual mistakes and TWEs which would affect the quality of cord blood and cord stem cells.
Controlled Rate Freezing	Built-in controlled rate freezer and eradicates TWEs Steady freezing rate at 2.8℃/min for optimal stem cells condition	External freezing procedure causing samples to get exposed to room temperature from -190℃ before storage. Extreme temperaure difference causes stem cells serious damage.(2-4% loss) Prolonged freezing time(~120 min) causes storage delay
Reassurance to you	Exclusive built-in controlled rate freezer allows the processing to be completed within a short period of time.
Stem Cells Quality	Over 97% viable CD34⁺ cells^clarify, unsurpassed among other cryopreservation systems Delivered up to 94% post-thaw cell viability¹³	Vapor Nitrogen combined with TWEs lead to 20% loss of viability²⁶
Reassurance to you	Using closed system and liquid nitrogen as storage media can maintain stem cells to their highest viability for future use.
Successful Transplants	Survival rate is 10% higher than traditional tanks after transplant¹⁴ Provided over 75% samples of successful transplants worldwide	Very few cases
Reassurance to you	Survival rate of patient who received stem cells for transplant from BioArchive^® System was 10% higher than those from using traditional vapor nitrogen storage system, providing trusted health protection to every expectant parent.
Global Usage	Adopted by over 80% Netcord’s cord blood banks Adopted by most public cord blood banks worldwide(including New York Cord Blood Center, Tokyo Cord Blood Bank and worldwide large blood banks). Since the cord blood samples are for local public use, the quality requirement is much higher than that of private blood bank, to ensure all samples reaching transplant standard Adopted by 60% cord blood banks in developed countries	Adopted by some private cord blood banks for cost saving concern
Reassurance to you	The only storage system in Hong Kong with the highest global quality recognition, incomparable by other private cord blood banks.
Cross Contamination	No cross contamination record No matter the cord blood stores in liquid nitrogen or vapor nitrogen, a cross-contamination might happen if containers are not airtight. Only sealed containers can eliminate eventual cross contaminations^24,25 Rumors in market that liquid nitrogen caused cross-contamination is false Reports showed sealed TG compartment molded freezing bags with liquid nitrogen storage can eradicate cross contamination^clarify Traditional tanks have no "Anti-Contamination" function and beware of this misleading term used by other cord blood banks	Cross contamination cases happpened^25,clarify

Transient Warming Events(TWEs) - Reduce Stem Cells Viability and Affect Transplant Quality

TWEs refers to temperature fluctuation resulting from transient exposure to surrounding air while the stem cells are being cryopreserved, taken out, transported and transferred to vapor nitrogen tanks for storage since they must operate in coordination with an external and independent freezing device. Such kind of repetitive temperature fluctuation will finally cause stem cells bursted and even died. Research report states that TWEs will reduce the number of stem cells even though it does not reach the significant level (>5%) in statistics. The fact is that millions of stem cells are lost due to TWEs¹⁸. Another report shows that Vapor Nitrogen combined with TWEs can lead to 20% loss of viability²⁶.

Why Cord Blood?