BioArchive^® System

Specifically designed for stem cells storage
Cleared by U.S. Food and Drug Administration (FDA)
Adopted by 129 cord blood banks in 37 countries
Adopted by worldwide large blood banks and 90% cord blood banks in Europe, as well as New York Blood Centre which performed most transplants worldwide
Provided over 75% stem cell samples of global cord blood transplants¹⁷
Survival rate is 10% higher than traditional tanks after transplant¹⁵
Robotic storage and retrieval system
Closed system handling, eliminating the TWEs occurred in traditional tanks, which affect stem cells viability for future transplant¹⁸
Use of liquid nitrogen (stable temperature at -196˚C) as storage media, which is recommended by reports for long-term stem cells storage¹⁹
Built-in computerized monitoring system with precise storage record. No external equipment needed
Liquid nitrogen reservoir can maintain stable temperature for more than 50 days without electricity supply
No quality issue and recall history with BioArchive in HealthBaby

Adopted by Worldwide Large Blood Banks and HealthBaby

FDA Cleared, never been compulsory recalled ^20,21. Worldwide large blood banks implemented the BioArchive system to enhance the efficiency and quality of cord blood storage. In addition, 90% of the cord blood bank in Europe adopted BioArchive^® system. It proves that this system is globally well recognized.

Cell Viability is the Key of Successful Rate of Transplants

Storing cord blood and umbilical cord is a lifetime safeguard for your children and families. No one wants to have chances to use one day, but if it really happens, have you ever thought of low viability of stem cells will let cord blood and umbilical cord lose its functions? HealthBaby introduced BioArchive^® liquid nitrogen storage system which is adopted by most of public cord blood bank in globe (including New York Cord Blood Center, Tokyo Cord Blood Bank and worldwide large blood banks), the purpose is to give the best safeguard for parents.

Use of liquid nitrogen (stable temperature at -196°C) as storage media is recommended by reports for long-term stem cells storage¹⁹. Only liquid nitrogen can keep stable -196°C amd cord blood stem cells will suspend all physiological activities and remain dormant. On the contrary, other cord blood banks claimed that stem cells can be stored at 135 ℃ for permanent storage while there is no scientific evidence to prove so. And using traditional vapor nitrogen tank will lead to temperature fuctuation resulting from transient exposure to surrounding air while the stem cells are being cryopreserved, taken out, transported and transferred to vapor nitrogen tanks for storage. Vapor Nitrogen combined with TWEs will lead to loss of viability.

HealthBaby Consultant

BioArchive^® - The Best Stem Cells Storage Quality

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	BioArchive^® System	Traditional Tanks
Specificity	FDA cleared, specifically designed for stem cells storage No compulsory recall by FDA due to stem cells quality^20,21	For biological samples storage previously
Storage Media	Liquid nitrogen(-196˚C) Stable temperature to maintain optimum stem cells viability^22,23 Constant temperature, permanent storage for over 1000 years¹⁹ Liquid nitrogen reservoir can maintain stable temperature for more than 50 days without electricity supply No quality issue and recall history with BioArchive in HealthBaby	Liquid (Adopted by HealthBaby) / vapor nitrogen The temperate of vapor nitrogen is unstable and may affect the viability of stem cells
Design and Operation	Closed design with stable storage temperature Independent access of samples by periscope without affecting others Eradicated TWEs, high stem cells viability guaranteed Built-in 24-hour surveillance system for instant alarm Manual mode to access samples for contingency Contains sample records only, no risk of hacking attacks to client information	Open system causing inconsistent temperature inside the tank²⁵ Shared compartment, accessing of one sample will also cause others exposed ti great temperature difference¹⁸ Transient Warming Events (TWEs) may affect stem cells viability^clarify Manual operation increases the risk of human errors
Controlled Rate Freezing	Built-in controlled rate freezer and eradicates TWEs Steady freezing rate at 2.8℃/min for optimal stem cells condition	External freezing procedure is required and samples have to experience unnecessary times to temperature differences and prolonged entry period
Transplant Quality	Survival rate is 10% higher than traditional tanks after transplant¹⁴ Provided over 75% samples of successful transplants worldwide	No significant increase in survival rate
Global Usage	Adopted by over 80% Netcord’s cord blood banks Adopted by most public cord blood banks worldwide(including New York Cord Blood Center, Tokyo Cord Blood Bank and worldwide large blood banks). Since the cord blood samples are for local public use, the quality requirement is much higher than that of private blood bank, to ensure all samples reaching transplant standard Adopted by 60% cord blood banks in developed countries	Mainly adopted by private cord blood banks
Cross Contamination	No cross contamination record No matter the cord blood stores in liquid nitrogen or vapor nitrogen, a cross-contamination might happen if containers are not airtight. Only sealed containers can eliminate eventual cross contaminations^24,25 Rumors in market that liquid nitrogen caused cross-contamination is false Reports showed sealed TG compartment molded freezing bags with liquid nitrogen storage can eradicate cross contamination^clarify Traditional tanks have no "Anti-Contamination" function and beware of this misleading term used by other cord blood banks	Cross contamination cases happpened^25,clarify

Transient Warming Events(TWEs) - Reduce Stem Cells Viability and Affect Transplant Quality

TWEs refers to temperature fluctuation resulting from transient exposure to surrounding air while the stem cells are being cryopreserved, taken out, transported and transferred to vapor nitrogen tanks for storage since they must operate in coordination with an external and independent freezing device. Such kind of repetitive temperature fluctuation will finally cause stem cells bursted and even died. Research report states that TWEs will reduce the number of stem cells even though it does not reach the significant level (>5%) in statistics. The fact is that millions of stem cells are lost due to TWEs¹⁸. Another report shows that Vapor Nitrogen combined with TWEs can lead to 20% loss of viability²⁶.

Why Cord Blood?