At present, over 113 diseases can be treated by cord blood5,6, including:

 

Leukemias


Acute Leukemia

  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myelogenous Leukemia (AML)
  • Acute Biphenotypic Leukemia
  • Acute Undifferentiated Leukemia

Chronic Leukemia

  • Chronic Lymphocytic Leukemia (CLL)
  • Chronic Myelogenous Leukemia (CML)
  • Chronic Myelomonocytic Leukemia
  • Juvenile Chronic Myelogenous Leukemia (JCML)
  • Juvenile Myelomonocytic Leukemia (JMML)

Myelodysplastic Syndromes

  • Refractory Anemia (RA)
  • Refractory Anemia with Ringed Sideroblasts (RARS)
  • Refractory Anemia with Excess Blasts (RAEB)
  • Refractory Anemia with Excess Blasts in Transformation (RAEB-T)
  • Chronic Myelomonocytic Leukemia (CMML)

Leukemia, Unspecified

 

 

Lymphomas


  • Hodgkin's Lymphoma
  • Non-Hodgkin's Lymphoma (Burkitt's Lymphoma)
  • Autoimmune Lymphoproliferative Disease
  • Lymphoma, Unspecified

 

 

Other Disorders of Blood Cell Proliferation


Bone Marrow Failure Syndromes

  • Congenital Dyserythropoietic Anemia
  • Dyskeratosis Congenita
  • Fanconi's Anemia
  • Paroxysmal Nocturnal Hemoglobinuria (PNH)
  • Shwachman-Diamond Syndrome
  • Severe Aplastic Anemia, Unspecified
  • Sideroblastic Anemia
  • Aplastic Anemia

Inherited Red Cell (Erythrocyte) Abnormalities

  • Thalassemia
  • Beta Thalassemia Major/ Cooley's Anemia
  • Diamond-Blackfan anemia
  • Pure Red Cell Aplasia
  • Sickle Cell Disease

Inherited Platelet Abnormalities

  • Amegakaryocytosis / Congenital Thrombocytopenia
  • Glanzmann Thrombasthenia

Inherited Immune System Disorders-Severe Combined Immunideficiency (SCID)

  • SCID with Adenosine Deaminase Deficiency (ADA-SCID)
  • SCID which is X-linked
  • SCID with Absence of T & B Cells
  • SCID with absence of T Cells, Normal B Cells
  • Omenn Syndrome

Inherited Immune System Disorders - Neutropenias

  • Kostmann Syndrome
  • Myelokathexis
  • Congenital Neutropenia

Myeloproliferative Disorders

  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia (Myelofibrosis)
  • Polycythemia Vera
  • Essential Thrombocythemia

Phagocyte Disorders

  • Chediak-Higashi Syndrome
  • Chronic Granulomatous Disease
  • Neutrophil Actin Deficiency
  • Reticular Dysgenesis

Bone Marrow Cancers

  • Multiple Myeloma
  • Plasma Cell Leukemia
  • Waldenstrom's Macroglobulinemia

Disorders of Cell Proliferation

  • Familial Erythrophagocytic Lymphistiocytosis
  • Hemophagocytic Syndrome
  • Hemophagocytic Lymphohistiocytosis
  • Histiocytosis
  • Langerhans Cell Histiocytosis

 

 

Inherited Disorders Effecting the Immune System & Other Organs


  • Cartilage-Hair Hypoplasia
  • Gunther's Disease / Congenital Erythropoietic Porphyria
  • Hermansky-Pudlak Syndrome
  • Pearson's Syndrome
  • Systemic Mastocytosis

 

 

Transplants for Inherited Metabolic Disorders


Mucopolysaccharidoses (MPS) Storage Diseases

  • Mucopolysaccharidoses (MPS)
  • Hurler's Syndrome (MPS-IH)
  • Hurler-Scheie Disease (MPS-IS)
  • Hunter's Syndrome (MPS-II)
  • Sanfilippo Syndrome (MPS-III)
  • Morquio Syndrome (MPS-IV)
  • Maroteaux-Lamy Syndrome (MPS-VI)
  • Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII)
  • Mucolipidosis II (I-cell Disease)

Leukodystrophy Disorders

  • Adrenoleukodystrophy (ALD) / Adrenomyeloneuropathy (AMN)
  • Krabbe Disease (Globoid Cell Leukodystrophy)
  • Metachromatic Leukodystrophy
  • Pelizaeus-Merzbacher Disease

Lysosomal Storage Diseases

  • Gaucher Disease
  • Niemann-Pick Disease
  • Sandhoff Disease
  • Tay-Sachs Disease
  • Wolman Disease

Metabolic / Storage Diseases

  • Alpha Mannosidosis
  • Amyloidosis
  • Aspartylglucosaminuria
  • Austin's Disease (Multiple Sulfatase Deficiency)
  • Fucosidosis
  • Gangliosidosis
  • Infantile Ceroid Lipofucoscinosis
  • Neiman-Pick Disease
  • Sialidosis

Inheritied Metabolic Disorders - Others

  • Lesch-Nyhan Syndrome
  • Osteopetrosis

 

 

Solid Tumors not Originating in the Blood or Immune System


  • Breast Cancer
  • Medulloblastoma
  • Neuroblastoma
  • Retinoblastoma
  • Other Malignancy

 

 

Miscellaneous


  • Epidermolysis Bullosa