At present, Haematopoietic stem cells or HSCs have been used to treat up to 113 diseases and Cord blood is a rich source of HSCs5,6. These treatable diseases include:
- Acute Lymphoblastic Leukemia (ALL)
- Acute Myelogenous Leukemia (AML)
- Acute Biphenotypic Leukemia
- Acute Megakaryocytic Leukemia
- Acute Undifferentiated Leukemia
- Atypical Chronic Myeloid Leukemia
- Bilineal Leukemia
- Biphenotypic Leukemia
- Chronic Lymphocytic Leukemia (CLL)
- Chronic Myelogenous Leukemia (CML)
- Chronic Neutrophilic Leukemia
- Hemophagocytic Lymphohistiocytosis (HLH)
- Juvenile Chronic Myelogenous Leukemia (JCML)
- Hemophagocytic Lymphohistiocytosis (HLH)
- Juvenile Chronic Myelogenous Leukemia (JCML)
- Juvenile Myelomonocytic Leukemia (JMML)
- Mixed Phenotype Acute Leukemia
- Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
- Therapy-Related Myelodysplastic Syndromes
Myelodysplastic Syndromes
- Refractory Anemia
- Refractory Anemia with Ringed Sideroblasts (Sideroblastic anemia)
- Refractory Anemia with Excess Blasts
- Refractory Anemia with Excess Blasts in Transformation
- Refractory Cytopenia
- Refractory Cytopenia
Lymphoma
- Anaplastic Large Cell Lymphoma
- Blastic Nk Cell Lymphoma
- Composite Lymphoma
- Follicular Lymphoma
- Hodgkin’s Lymphoma
- Mantle Cell Lymphoma
- Mycosis Fungoides
- Non-Hodgkin’s Lymphoma (Burkitt’s Lymphoma)
- Peripheral T-Cell Lymphoma
Other Disorders of Blood Cell Proliferation
Anemias
- Aplastic Anemia
- Congenital Dyserythropoietic Anemia
- Dyskeratosis Congenita
- Fanconi Anemia
- Paroxysmal Nocturnal Hemoglobinuria (PNH)
Inherited Red Cell Abnormalities Red cells
- Beta Thalassemia Major (aka Cooley’s Anemia)
- Diamond-Blackfan Anemia
- Pure Red Cell Aplasia
- Sickle Cell Disease
Inherited Platelet Abnormalities Platelets
- Amegakaryocytosis / Congenital Thrombocytopenia
- Glanzmann Thrombasthenia
Inherited Immune System Disorders: Severe Combined Immunodeficiency
- Combined Immunodeficiency
- SCID with Adenosine Deaminase Deficiency (ADA-SCID)
- SCID which is X-linked
- SCID with absence of T & B Cells
- SCID with absence of T Cells, Normal B Cells
- Omenn Syndrome
Inherited Immune System Disorders: Neutropenias
- Congenital Neutropenia
- Infantile Genetic Agranulocytosis (Kostmann Syndrome)
- Myelokathexis
Inherited Immune System Disorders: Others
- Ataxia-Telangiectasia
- Bare Lymphocyte Syndrome
- Common Variable Immunodeficiency
- DiGeorge Syndrome
- Familial Hemophagocytic Lymphohistiocytosis Type 2
- Farber Disease
- Immune Deficiency
- Hemophagocytic Lymphohistiocytosis
- Histiocytosis
- Leukocyte Adhesion Deficiency
- Lymphoproliferative Disorders
- Lymphoproliferative Disorder, X-linked (Susceptibility to Epstein-Barr virus)
- Purine Nucleoside Phosphorylase Deficiency
- Hyper Igm Syndrome
- X-Linked Lymphoproliferative Disease
- X-Linked Chronic Granulomatous Disease
- Wiskott-Aldrich Syndrome
Inherited Immune System Disorders: Others
- Ataxia-Telangiectasia
- Bare Lymphocyte Syndrome
- Common Variable Immunodeficiency
- DiGeorge Syndrome
- Familial Hemophagocytic Lymphohistiocytosis Type 2
- Farber Disease
- Immune Deficiency
- Hemophagocytic Lymphohistiocytosis
- Histiocytosis
- Leukocyte Adhesion Deficiency
- Lymphoproliferative Disorders
- Lymphoproliferative Disorder, X-linked (Susceptibility to Epstein-Barr virus)
- Purine Nucleoside Phosphorylase Deficiency
- Hyper Igm Syndrome
- X-Linked Lymphoproliferative Disease
- X-Linked Chronic Granulomatous Disease
- Wiskott-Aldrich Syndrome
Myeloproliferative Disorders
- Acute Myelofibrosis
- Agnogenic Myeloid Metaplasia (Myelofibrosis)
- Blastic Plasmacytoiddendritic Cell Neoplasm
- Polycythemia Vera
- Essential Thrombocythemia
- Myelodysplastic Syndrome
- Myeloma Multiplex
Phagocyte Disorders
- Chediak-Higashi Syndrome
- Chronic Granulomatous Disease
- Neutrophil Actin Deficiency
- Reticular Dysgenesis
Bone Marrow Cancers
- Multiple Myeloma
- Plasma Cell Leukemia
- Waldenstrom’s Macroglobulinemia
Transplants for Inherited Disorders of the Immune System & Other Organs
- Cartilage-Hair Hypoplasia
- Erythropoietic Porphyria
- Hermansky-Pudlak Syndrome
- Pearson’s Syndrome
- Shwachman-Diamond Syndrome
- Systemic Mastocytosis
Transplants for Inherited Metabolic Disorders
Mucopolysaccharidosis (MPS) Storage Diseases
- Hurler Syndrome (MPS-IH)
- Scheie Syndrome (MPS-IS)
- Hunter Syndrome (MPS-II)
- Sanfilippo Syndrome (MPS-III)
- Morquio Syndrome (MPS-IV)
- Maroteaux-Lamy Syndrome (MPS-VI)
- Sly Syndrome (MPS-VII) (beta-glucuronidase deficiency)
- Mucolipidosis II (I-cell Disease)
Leukodystrophy Disorders
- Adrenoleukodystrophy (ALD)
- Krabbe Disease(Globoid Cell Leukodystrophy)
- Metachromatic Leukodystrophy
- Pelizaeus-Merzbacher Disease
Lysosomal Storage Diseases
- Niemann-Pick Disease
- Sandhoff Disease
- Wolman Disease
Inherited Metabolic Disorders: Others
- Lesch-Nyhan Syndrome
- Osteopetrosis
Solid tumors not originating in the blood or immune system
- Neuroblastoma
- Medulloblastoma
- Retinoblastoma
- Erdheim Chester Disease
- Extracranial Malignant Germ Cell Tumors
- Nijmegen Breakage Syndrome
Document code: EP-013-2022
